How can the Jorinde L-Detoxin Detox Cure help the body detoxify its cells?
The glutathione from the branded ingredient Lalmin® Detox detoxifies in three ways:
1. Direct Conjugation (Phase II)
The enzyme glutathione S-transferase (GST) covalently links glutathione to lipophilic foreign substances such as pesticides, drug metabolites, and reactive carbon compounds. The resulting conjugate is water-soluble and is excreted via bile or kidneys.[1]
2. Peroxide Degradation
Glutathione peroxidase (GPx) uses glutathione to neutralize hydrogen peroxide and lipid peroxides. In this process, glutathione is oxidized (GSSG) and subsequently regenerated by glutathione reductase.[2]
3. Heavy Metal Binding
Through its thiol group (-SH), glutathione forms complexes with heavy metals such as mercury, cadmium, and arsenic. These are further processed in the liver and excreted via bile or—after conversion into mercapturic acid—renally.[3]
The selenium content in Lalmin® Detox is functionally relevant: selenium is a cofactor of GPx, without which peroxide degradation does not run efficiently.[2]
- Hayes JD, Flanagan JU, Jowsey IR. Glutathione transferases. Annu Rev Pharmacol Toxicol. 2005;45:51–88. Overview of the role of GST in phase II conjugation and excretion of lipophilic xenobiotics. PubMed
- Brigelius-Flohé R, Maiorino M. Glutathione peroxidases. Biochim Biophys Acta. 2013;1830(5):3289–3303. Mechanism of GPx-mediated peroxide detoxification and the importance of selenium as a cofactor. PubMed
- Ballatori N, Krance SM, Notenboom S, et al. Glutathione dysregulation and the etiology and progression of human diseases. Biol Chem. 2009;390(3):191–214. Describes the role of glutathione in the hepatic processing and renal excretion of heavy metal conjugates. PubMed
